Jan 3, 2023Liked by Metacelsus

I wouldn't be so quick to judge JK on his choice of method. Stem cell nuclear transfer is obviously superior, but parents want a child that results from their gametes (necessitating the use of embryonic stem cells for the modification), and the retention of correct imprinting in cultured ESCs wasn't solved until a few years later. How big of an issue that imprinting would be in humans isn't known, but I wouldn't want to be the one to find out. Not to mention that, if He went the adult stem cell route instead, the baby being a clone might've been even bigger news.

His choice to do it in the first place was misguided, certainly, due to the questionable gene target (given modern medicine), the risks of off-target and mosaic mutations inherent to CRISPR microinjection, and the amount of blowback it caused for the field.

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