Toxoplasma need high levels of linoleic acid for sexual reproduction and cats don’t have an enzyme necessary for break down so it just builds up in their intestinal epithelium.
The idea would be to make a diploid stem cell line do meiosis, genotype the haploid stem cell lines, and then combine 2 top ones into a diploid line. Repeat as needed.
Toxoplasma need high levels of linoleic acid for sexual reproduction and cats don’t have an enzyme necessary for break down so it just builds up in their intestinal epithelium.
The idea would be to make a diploid stem cell line do meiosis, genotype the haploid stem cell lines, and then combine 2 top ones into a diploid line. Repeat as needed.
Selection at the haploid stage would give similar advantages to gamete selection. See: https://www.gwern.net/Embryo-selection#gamete-selection