I went home early from the lab today, since yesterday I got my Comirnaty booster and now my immune system has declared that I Am Tired. I decided that instead of being totally unproductive, I’ll be slightly productive and write a blog post. Anyway, here are some random ideas and updates from my life:
Toxoplasma need high levels of linoleic acid for sexual reproduction and cats don’t have an enzyme necessary for break down so it just builds up in their intestinal epithelium.
I'm not sure I understand your #5. If I'm genotyping before fertilization, aren't I not getting enough information? Wouldn't it be better to genotype after fertilization?
The idea would be to make a diploid stem cell line do meiosis, genotype the haploid stem cell lines, and then combine 2 top ones into a diploid line. Repeat as needed.
Toxoplasma need high levels of linoleic acid for sexual reproduction and cats don’t have an enzyme necessary for break down so it just builds up in their intestinal epithelium.
I'm not sure I understand your #5. If I'm genotyping before fertilization, aren't I not getting enough information? Wouldn't it be better to genotype after fertilization?
The idea would be to make a diploid stem cell line do meiosis, genotype the haploid stem cell lines, and then combine 2 top ones into a diploid line. Repeat as needed.
Selection at the haploid stage would give similar advantages to gamete selection. See: https://www.gwern.net/Embryo-selection#gamete-selection
Thank you! This topic is so interesting!