What would it take, to make yeast that make psilocin/psilocybin? The relevant enzymes are already present in “magic mushrooms” and yeast is also a fungus. Psilocybin-producing yeast have already been engineered in an academic lab. These yeast also produced a lot of psilocin (the dephosphorylated analog) as a side product, but that’s OK because psilocin is actually the active molecule.
You could probably reproduce published work without too much difficulty. But, yeast metabolic engineering isn't easy. It took many publications and hundreds of thousands of man-hours to develop the Artemisinin yeast to an acceptable level of productivity.
There's also a yeast that could brew alcohol that would make you high:
Reminds me of 3D printed guns.
I love this idea. I have no idea how to make it a reality.
You could probably reproduce published work without too much difficulty. But, yeast metabolic engineering isn't easy. It took many publications and hundreds of thousands of man-hours to develop the Artemisinin yeast to an acceptable level of productivity.
There's also a yeast that could brew alcohol that would make you high:
https://www.nature.com/articles/s41586-019-0978-9
The legality of it would be a separate issue. The cannabinoid paper says that DEA papers are needed to get their yeast.