Isn't this article talking about doing exactly that? Milne N, Thomsen P, Mølgaard Knudsen N, Rubaszka P, Kristensen M, Borodina I. Metabolic engineering of Saccharomyces cerevisiae for the de novo production of psilocybin and related tryptamine derivatives. Metab Eng. 2020 Jul;60:25-36. doi: 10.1016/j.ymben.2019.12.007. Epub 2020 Mar 26. PMID: 32224264; PMCID: PMC7232020.
You could probably reproduce published work without too much difficulty. But, yeast metabolic engineering isn't easy. It took many publications and hundreds of thousands of man-hours to develop the Artemisinin yeast to an acceptable level of productivity.
There's also a yeast that could brew alcohol that would make you high:
Isn't this article talking about doing exactly that? Milne N, Thomsen P, Mølgaard Knudsen N, Rubaszka P, Kristensen M, Borodina I. Metabolic engineering of Saccharomyces cerevisiae for the de novo production of psilocybin and related tryptamine derivatives. Metab Eng. 2020 Jul;60:25-36. doi: 10.1016/j.ymben.2019.12.007. Epub 2020 Mar 26. PMID: 32224264; PMCID: PMC7232020.
I love this idea. I have no idea how to make it a reality.
You could probably reproduce published work without too much difficulty. But, yeast metabolic engineering isn't easy. It took many publications and hundreds of thousands of man-hours to develop the Artemisinin yeast to an acceptable level of productivity.
There's also a yeast that could brew alcohol that would make you high:
https://www.nature.com/articles/s41586-019-0978-9
The legality of it would be a separate issue. The cannabinoid paper says that DEA papers are needed to get their yeast.