In my last post on epigenetics, I argued that transgenerational epigenetic inheritance in mammals is weak to nonexistent. This is because epigenetic marks are erased between generations, both in the early embryo and prior to gamete development. But, even if transgenerational epigenetic inheritance is too weak to be important in a natural setting, it might be possible to induce experimentally with a very strong epigenetic perturbation. Such an experiment would provide an upper bound on what we might expect to see in nature.
Please explain this if you get a chance. In the beginning of the paper when methylation was induced there seems to be a discrepancy regarding the percent methylation of the Ankrd26 CGI. First it states "with two of them showing more than 55% of CpGs methylated" and then it states "Ankrd HR1ex exhibited 85.2% methylation on Ankrd26 CGI". did the methylation go up in the HRex? if so there seems to the opposite effect in the Ldlr CGI.
Wow! Heritable through F4! I hope the readership grasps how significant this is!l. Great work Metacelsus in opening up a can of alleles! What indeed is going on? I'm just a mere philosopher and CA engineer, but I think this stuff is exciting. Are the Chinese research teams publishing their research?
Please explain this if you get a chance. In the beginning of the paper when methylation was induced there seems to be a discrepancy regarding the percent methylation of the Ankrd26 CGI. First it states "with two of them showing more than 55% of CpGs methylated" and then it states "Ankrd HR1ex exhibited 85.2% methylation on Ankrd26 CGI". did the methylation go up in the HRex? if so there seems to the opposite effect in the Ldlr CGI.
Wow! Heritable through F4! I hope the readership grasps how significant this is!l. Great work Metacelsus in opening up a can of alleles! What indeed is going on? I'm just a mere philosopher and CA engineer, but I think this stuff is exciting. Are the Chinese research teams publishing their research?